AKOS B033080

AKOS B033080 - Names and Identifiers

Name	4-[3-(Trifluoromethyl)phenoxy]aniline
Synonyms	AKOS B033080 4-(3-TRIFLUOROMETHYLPHENOXY)ANILINE 4-[3-(Trifluoromethyl)phenoxy]aniline Benzenamine, 4-[3-(trifluoromethyl)phenoxy]-
CAS	41605-31-6
InChI	InChI=1/C13H10F3NO/c14-13(15,16)9-2-1-3-12(8-9)18-11-6-4-10(17)5-7-11/h1-8H,17H2

AKOS B033080 - Physico-chemical Properties

Molecular Formula	C13H10F3NO
Molar Mass	253.22
Density	1.293g/cm³
Boling Point	140°C/5mm
Flash Point	148.5°C
Vapor Presure	0.00029mmHg at 25°C
Refractive Index	1.545

AKOS B033080 - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

AKOS B033080 - Introduction

4-[3-(Trifluoromethyl)phenoxy]aniline is an organic compound whose chemical formula is C13H10F3NO. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White solid
-Solubility: Soluble in some organic solvents, such as ethanol and dimethylformamide
-Melting point: about 58-62°C
-Molecular weight: 267.22g/mol

Use:
- 4-[3-(Trifluoromethyl)phenoxy]aniline is commonly used as an intermediate in pharmaceuticals or pesticides. It can be used to synthesize compounds with different biological activities, such as drugs and pesticides.
-In organic synthesis, it can also be used as a substitution reaction reagent for aromatic compounds.

Preparation Method:
- 4-[3-(Trifluoromethyl)phenoxy] One method of synthesis of aniline is through the substitution reaction of aniline. First, trifluoroformic acid is added to aniline under basic conditions to produce the corresponding trifluoromethylaniline. Then, 3-trifluoromethylaniline is subjected to an oxidative coupling reaction with phenol to form 4-[3-(Trifluoromethyl)phenoxy]aniline under basic conditions.

Safety Information:
-When using or handling 4-[3-(Trifluoromethyl)phenoxy]aniline, necessary laboratory safety measures should be taken, such as wearing gloves, laboratory clothing and eye protection.
-The compound may be irritating to the eyes and skin and can cause allergic reactions.
-Avoid inhaling its dust or vapors. In case of overdose, immediately go to an air circulation area for fresh air and seek medical help.
-When storing and handling this compound, follow the relevant safety procedures.

Last Update：2024-04-09 21:01:54